| Chemistry 17 | Principles of Organic Chemistry Eric N. Jacobsen An introduction to organic chemistry, with an emphasis on structure and bonding, reaction mechanisms, and chemical reactivity. |
| Chemistry 20 | Organic Chemistry Ryan M. Spoering An introduction to structure and bonding in organic molecules; mechanisms of organic reactions; chemical transformations of the functional groups of organic chemistry; synthesis; determination of chemical structures by infrared and NMR spectroscopy. |
| Chemistry 27 | Organic Chemistry of Life Marie Colleen Spong Chemical principles that govern the processes driving living systems are illustrated with examples drawn from biochemistry, cell biology, and medicine. The course deals with organic chemical reactivity (reaction mechanisms, structure-reactivity relationships), with matters specifically relevant to the life sciences (chemistry of enzymes, nucleic acids, drugs, natural products, cofactors), and with applications of chemical biology to medicine and biotechnology. An understanding of organic reactions and their "arrow" pushing mechanisms is required. |
| Chemistry 30 | Organic Chemistry Tobias Ritter Continuation of Chemistry 20. Fundamental principles and advanced topics in organic chemistry. Carbonyl chemistry and pericyclic reactions are covered in particular detail, using principles of stereochemistry, stereoelectronic theory, and molecular orbital theory as a foundation. Students learn about strategies in multi-step organic synthesis and are given an introduction into organometallic chemistry. Laboratory: an introduction to organic chemistry laboratory techniques and experimental organic synthesis. |
| Chemistry 40 | Inorganic Chemistry Daniel Nocera An introduction to basic concepts of inorganic chemistry. Develops principles of chemical bonding and molecular structure on a basis of symmetry, applying these concepts to coordination chemistry (highlighting synthesis), organometallic chemistry (applications to catalysis), materials synthesis, and bioinorganic processes. |
| Chemistry 60 | Foundations of Physical Chemistry Roy G. Gordon A compact introduction to major principles of physical chemistry (statistical mechanics, thermodynamics, and chemical kinetics ), concurrently providing mathematical and physical foundations for these subjects and preparation for Chemistry 160 and 161. |
| Chemistry 91 r | Introduction to Research Gregory C. Tucci and members of the Department Reading and/or laboratory work related to one of the research projects under way in the department. |
| Chemistry 98 r | Introduction to Research-Junior Year Gregory C. Tucci and members of the Department Research under the direction of, or approved by, a member of the faculty of the Department of Chemistry. |
| Chemistry 99 r | Tutorial-Senior Year Gregory C. Tucci and members of the Department Research under the direction of, or approved by, a member of the faculty of the Department of Chemistry. |
| Chemistry 100 r | Experimental Chemistry and Chemical Biology Ryan M. Spoering (fall term) and Austin Bennett Scharf (spring term) A laboratory course where students carry out research. Projects will be drawn directly from faculty covering a range of methodologies in chemistry and chemical biology. Students will discuss their progress and write formal reports. |
| Chemistry 101 | Organic Synthesis Towards a Genomic Medicine Stuart L. Schreiber Organic Synthesis Towards a Genomic Medicine teaches students principles of modern organicsynthesis, chemical biology and genome biology relevant to the discovery of safe and effective therapeutics in the future. The course will then explore patient-based 'experiments of nature' that illuminate disease, including cancer, diabetes, infectious disease and psychiatric disease, among others. Students will then use their knowledge of chemistry and chemical biology to propose research yielding novel small molecules that emulate the experiments of nature. Chem 101 aims to prepare students for the next decade where academic research tests hypotheses emerging from humanbiology in humans using novel small-molecule probes. |
| Chemistry 106 | Advanced Organic Chemistry Eugene Elliott Kwan This course will survey modern organic chemistry from a fundamental perspective. The foundations of structure and bonding, donor-acceptor interactions, and conformational analysis will be considered in the context of pericyclic reactions and cyclic and acyclic stereocontrol. The behavior of reactive intermediates, the basis for enantioselective catalysis, and patterns in functional group reactivity will also be discussed. |
| Chemistry 110 | Small Molecules and Biological Processes Matthew D. Shair Small molecules are extraordinarily useful tools to investigate biological processes, perturb cell states and treat human diseases. They are complementary to many biological techniques (e.g. expression of mutant proteins, RNAi, genome editing and antibodies) in that they are fast-acting, typically cell permeable, easily reversible, and they can engage multiple targets simultaneously. In this course, we will discuss how these useful small molecules are discovered, how they have revealed deep insights into biological processes, and how they are employed as therapeutics. |
| Chemistry 115 | Advanced Organic Chemistry: Synthesis of Complex Molecules Andrew G. Myers An integrated course in complex synthetic problem solving that focuses on the development of principles and strategies for synthesis design with a concurrent, comprehensive review of modern synthetic transformations. |
| Chemistry 117 | Practical NMR Spectroscopy Eugene Elliott Kwan This course examines the application of modern NMR spectroscopic techniques to the structural elucidation of small molecules. Both the practical and theoretical aspects of 1D and 2D NMR experiments will be explored. Topics include: the chemical shift; coupling constants; the nuclear Overhauser effect and relaxation; chemical exchange; 2D homonuclear and heteronuclear correlation; analysis of complex molecules with overlapping signals and data tabulation; analysis of reactive intermediates; kinetics by NMR; the Fourier transform; quadrature detection; phase-sensitive detection; the vector model; the density matrix and the product operator formalism; pulsed field gradients; and spectrometer instrumentation. |
| Chemistry 135 | Experimental Synthetic Chemistry Eugene Elliott Kwan An introduction to experimental problems encountered in the synthesis, isolation, purification, characterization, and identification of inorganic and organic compounds. Student work on projects in chemical synthesis, encouraging technical proficiency and simulating actual research. |
| Chemistry 145 | Experimental Inorganic Chemistry Theodore A. Betley and Austin Bennett Scharf An introduction to experimental problems encountered in the synthesis, isolation, purification, characterization, and identification of inorganic compounds, with an emphasis in air-free synthetic techniques and spectroscopic characterization methods specifically applicable to complexes containing transition metals. |
| Chemistry 153 | Organotransition Metal Chemistry Tobias Ritter An introduction to transition metal-mediated chemistry. Topics include organometallic reaction mechanisms and transition metal catalysis in synthesis. Design, development, and presentation of research ideas, relevant to contemporary catalysis and the current literature will be taught as part of the course. |
| Chemistry 154 | Advanced Inorganic Chemistry Daniel Nocera The physical inorganic chemistry of transition elements will be discussed. The course will emphasize group theoretical methods of analysis and attendant spectroscopic methods (e.g., electronic, vibrational, EPR, magnetic) derived therefrom. Connections between molecular structure and electronic structure and how that parlays into the properties of complexes and their reactivity will be illustrated throughout various modules, which will touch on advanced problems of interest in the subjects of catalytic, organometallic, coordination, solid state and bioinorganic chemistries. |
| Chemistry 155 | Advanced Inorganic Chemistry II Theodore A. Betley Transition element chemistry will be discussed with an emphasis on synthesis, structure, bonding, and reaction mechanisms. Connections between molecular structure and electronic structure and how that parlays into reactivity will be emphasized throughout. Advanced problems of interest to inorganic chemistry will be discussed in the context of catalysis, organometallics, and bioinorganic processes. The course will be discussion driven with a heavy reliance on the current literature. |
| Chemistry 156 | Chemistry of Positron Emission Tomography Jacob M. Hooker (Medical School) This course will provide exposure to translational imaging from a unique chemical perspective. The focus of the course will be radiotracer chemistry but additional topics such as imaging physics, imaging equipment, and probe design based on biology, pharmacokinetics, and image analysis will be covered. Students will leave the course with working knowledge of radiotracer design and human translational imaging. |
| Chemistry 158 | Nanoscience and Nanotechnology Charles M. Lieber A survey of nanoscience and nanotechnology. Topics include: bottom-up versus top-down paradigms; synthesis and fabrication of zero-, one-and two-dimensional materials; physical properties of nanostructures, including electronic and optical properties; hierarchical organization in two and three dimensions; functional devices circuits and nanosystems; applications with emphasis on nano-bio interface and electronics. |
| Chemistry 160 | The Quantum World Alan Aspuru-Guzik Many essential properties of atoms, molecules and materials stem from their quantum mechanical nature. In this course, we will focus on the quantum mechanical aspects of physical chemistry. The basic principles of quantum mechanics will be introduced in tandem with the chemical concepts covered. We will describe the quantum mechanics of molecular bonding, vibrations and rotations. The fundamentals of molecular spectroscopy and photophysics will be seen in the light of quantum mechanics. We will end the course by introducing what goes behind the sciences in quantum chemistry packages for calculating molecular electronic structure and molecular properties. This year, the course will employ online forums for student discussions and turning in homework assignments. Most of the materials for evaluation will be take-home team programming exercises written in interactive Phython (iPhython). There will be no final exam. |
| Chemistry 161 | Statistical Thermodynamics Binny Joseph Cherayil An introduction to statistical mechanics, thermodynamics, and chemical kinetics with applications to problems in chemistry and biology. |
| Chemistry 163 | Frontiers in Biophysics Xiaoliang Sunney Xie This course introduces the physical chemistry underpinnings of life processes, including thermodynamics, equilibrium and nonequilibrium statistical mechanics and chemical kinetics. These principles will be illustrated in the context of recent experimental advances, in particular single-molecule enzymology, molecular motors, live cell imaging, and stochastic gene expression. Statistical analyses and numerical simulations of important biological processes will be covered throughout the course. |
| Chemistry 165 | Experimental Physical Chemistry Cynthia M. Friend Hands-on introduction to physical methods and techniques used widely in chemistry and chemical physics research laboratories. Computer-based methods of data acquisition and analysis are used throughout. |
| Chemistry 170 | Chemical Biology Alan Saghatelian Applying chemical approaches to problems in biology. Topics include: protein engineering and directed evolution; RNA catalysis and gene regulation; chemical genetics, genomics, and proteomics; drug action and resistance; rational and combinatorial approaches to drug discovery; metabolic engineering. |
| Chemistry 171 | Biological Synthesis Emily Patricia Balskus This course will examine synthesis from a biological perspective, focusing on how organisms construct and manipulate metabolites, as well as how biological catalysts and systems can be used for small molecule production. Topics to be covered include mechanistic enzymology, biosynthetic pathways and logic, biocatalysis, protein engineering, and synthetic biology. |
| Chemistry 190 | Statistical Mechanics in Chemistry and Biology Eugene I. Shakhnovich This course will cover interdisciplinary aspects of Chemistry and Biology where Statistical Mechanics played a pivotal role. Topics include: Polymers in solution and condensed phases, equilibrium and dynamics of self-assembly -layers and micelles, protein folding, structure and bioinformatics, reaction dynamics on complex energy landscapes, dynamic and evolution of complex networks. |
| Chemistry 205 | Advanced Physical Organic Chemistry Eric N. Jacobsen An in-depth perspective on mechanistic organic chemistry, with analysis of fundamental organic and organotransition metal reaction mechanisms, reactive intermediates, catalysis, stereochemistry, non-covalent interactions, and molecular recognition. Classical and modern tools of physical-organic chemistry, including reaction kinetics, computer modeling, isotope effects, and linear free-energy relationships will be evaluated in the context of literature case studies. |
| Chemistry 207 | Advanced Organic Synthesis and Reactions Matthew D. Shair This course presents reactivity principles of organic molecules. Topics include frontier molecular orbital theory, stereoelectronic effects, conformational analysis, cationic, anionic, radical, and carbene intermediates. These reactivity principles are used in a presentation of target-oriented synthesis. Strategies and tactics for assembling complex organic molecules are presented. |
| Chemistry 218 | Advanced Semiclassical Methods for Quantum Mechanics Eric J. Heller Semiclassical approaches to quantum systems provide both intuitive understanding of quantum processes and methods for calculations that are vastly simpler than full quantum mechanical simulations. Semiclassical methods are based on classical mechanics including interference and phases computed with classical actions. The course, based on a textbook being written by Prof. Heller (The Semiclassical Way to Quantum Mechanics) begins with a review of some salient features of classical physics, followed by an introduction to stationary phase integration and the Feynman Path Integral in the semiclassical imit, including time and energy domains, and the famous Trace Formula. This is followed by a number if widely useful techniques, such as generalized tunneling, applications to classically chaotic systems,semiclassical wave packet dynamics, WKB methods and uniformization. A number of "special topics" will then be taken up, including decoherence, certain forms of spectroscopy, and scattering theory of nanoscale devices. |
| Chemistry 240 | Statistical Thermodynamics Eugene I. Shakhnovich An introduction to statistical mechanics, thermodynamics, and chemical kinetics with strong emphasis on applications to problems in chemistry and biology. Topics include: thermodynamics and statistical properties of gases, liquids and crystals, critical phenomena, elements of non-equilibrium statistical mechanics with applications to Chemistry and Biophysics such as theories for biopolymers and chemical reactions. |
| Chemistry 242 | Quantum Mechanics for Physical Chemistry Kang-Kuen Ni This course describes the quantum mechanics of molecules and their chemical reactions. We review fundamental principles: Hilbert spaces, operator algebra, Schrodinger, Heisenberg and interaction pictures. Quantum mechanics applied to the understanding of molecular structure, spectra, chemical bonds, and chemical reaction dynamics. Modern techniques for the manipulation of molecular internal and external quantum states. |
| Chemistry 243 | Applied Quantum Mechanics Hongkun Park The course will cover the application of quantum mechanical principles to contemporary problems in chemistry and physics. The topics covered in the course will include: chemical bonding and the Born-Oppenheimer Approximation, atom/molecule-photon interaction (including second quantization and the dressed-state approach), Quantum Optics, and solid-state and nano-science (band theory, Fermi liquid theory, and electron transport). |
| Chemistry 245 | Classical, Quantum, and Semiclassical Dynamics and Scattering Eric J. Heller Semiclassical approaches to quantum systems provide both intuitive understanding ofquantum processes and methods for calculations that are vastly simpler than full quantummechanical simulations. Seminclassical methods are based on classical mechanics includinginterference and phases computed with classical actions. The course, based on a textbookbeing written by Prof. Heller (The Semiclassical Way to Quantum Mechanics) begins with a review of some salient features of classical physics, followed by an introduction to stationary phaseintegration and the Feynman Path Integral in the semi classical limit, including time and energydomains, and the famous Trace Formula. This is followed by a number of widely useful techniques,such as generalized tunneling, applications to classically chaotic systems, semiclassical wavepacket dynamics, WKB methods and uniformization. A number of "special topics" will then betaken up, including decoherence, certain forms of spectroscopy, and scattering theory ofnanoscale devices. |
| Chemistry 253 | Modeling Matter at Nanoscale: An Introduction to Theoretical and Computational Approaches Luis Alberto Montero Cabrera Essentials of modeling the structure of matter at the nanoscale. Material properties and connections to the mesocale. Intended for advanced undergraduate students or beginning graduate students in Chemistry, Physics, Applied Physics and the Life Sciences. |
| Chemistry 255 | Practical Crystallography in Chemistry and Materials Science Shao-Liang Zheng Due to great technical advances, crystal structure analysis plays an increasingly important role in the structure determination of complex solids. This course involves the basic principles of crystallography and covers advanced aspects of practical crystal structure refinement. Topics include crystal symmetry, space groups, geometry of diffraction, structure factors, and structure refinement. Students will gain a working knowledge of x-ray crystallographic techniques, including how to: grow quality crystals, collect data, reduce data, determine a structure, visualize structure, utilize structural databases, publish crystallographic results. Watch Learning Crystal Structure Analysis at Harvard. |
| Chemistry 267 | Surface and Interfacial Phenomena Cynthia M. Friend General principles governing surface and interfacial phenomena are developed using treatment of surface electronic and geometric structure as a foundation. The course will treat both theoretical and experimental tools for the investigation of surface structure. Selected spectroscopic techniques will also be treated, with emphasis on surface phenomena. The latter part of the course will develop principles of absorption, reaction, and growth phenomena illustrated through current literature topics. |
| Chemistry 300 | Research and Reading Individual work under the supervision of members of the Department. |
| Chemistry 301 hf | Scientific Teaching and Communications: Practicum This course will teach graduate students how to communicate scientific concepts in the classroom. Students will focus on becoming effective teachers in discussion sections and in the laboratory. The course will emphasize hands-on experience in teaching and explaining scientific concepts. |
| Chemistry 302 | Organometallic Chemistry |
| Chemistry 303 | Organic Chemistry |
| Chemistry 305 qc | Responsible Conduct of Research (RCR) Chemistry 305qc uses case studies to examine basic ethical and regulatory requirements for conducting research, and fulfills the National Science Foundation (NSF) and National Institutes of Health (NIH) requirements for formal Responsible Conduct of Research (RCR) instruction. Topics covered include: research and professional conduct; responsible authorship and publication; mentor-mentee relationships; conflicts of interest; peer review; grant writing and budgeting; intellectual property; data acquisition and management; ownership of data and biological samples; and research involving human and animal subjects. Students are required to attend all lectures, participate in class discussions, and complete a final course evaluation. A certificate will be issued upon successful completion of the course. |
| Chemistry 311 | Physical Chemistry |
| Chemistry 315 | Photochemistry and Kinetics |
| Chemistry 318 | Organic Chemistry |
| Chemistry 320 | Chemical Biology |
| Chemistry 323 | Organic Chemistry |
| Chemistry 325 | Physical Chemistry |
| Chemistry 326 | Physical Chemistry and Atomic Physics |
| Chemistry 330 | Physical Chemistry |
| Chemistry 331 | Approaches Toward Understanding and Treating Human Disease |
| Chemistry 336 | Physical and Inorganic Chemistry and Materials Science |
| Chemistry 340 | Inorganic Chemistry |
| Chemistry 342 | Inorganic Chemistry |
| Chemistry 350 | Theoretical Physical Chemistry |
| Chemistry 386 | Theoretical Chemistry |
| Chemistry 387 | Organic Chemistry |
| Chemistry 388 | Organic Chemistry |
| Chemistry 389 | Physical Chemistry |
| Chemistry 391 | Physical Chemistry |
| Chemistry 393 | Physical Chemistry |
| Chemistry 396 | Organic Chemistry |
| Chemistry 397 | Organic Chemistry |
| Chemistry 398 | Organic and Organometallic Chemistry |
| Chemistry 399 | Biochemistry and Chemical Biology |
| Life and Physical Sciences 0 A | Foundational Chemistry and Biology Gregory C. Tucci and Tamara J. Brenner This course introduces fundamental concepts in chemistry and biology. Topics in chemistry include stoichiometry, acids and bases, aqueous solutions, gases, thermochemistry, electrons in atoms, and chemical bonding. The course also examines biological molecules, the transfer of information from DNA to RNA to protein, and cell structure and signaling. |
| Physical Sciences 1 | Chemical Bonding, Energy, and Reactivity: An Introduction to the Physical Sciences Hongkun Park, Lindsay M. Hinkle, and Sirinya Matchacheep The course covers the chemistry and physics underlying molecular phenomena in the world. Starting from a single electron, the course will build up to atoms, molecules, and materials. Interactions of molecules are studied through thermochemistry, equilibria, entropy and free energy, acids and bases, electrochemistry, and kinetics. Applications include physical principles in biology, global energy demands, and modern materials and technology. |
| Physical Sciences 10 | Quantum and Statistical Foundations of Chemistry Adam E. Cohen An introduction to the fundamental theories of quantum mechanics and statistical mechanics and their role in governing the behavior of matter. The course begins with the quantum behavior of a single electron and develops the elements of the periodic table, the nature of the chemical bond, and the bulk properties of materials. Applications include semiconductor electronics, solar energy conversion, medical imaging, and the stability and dynamism of living systems. Calculus will be used extensively. |
| Physical Sciences 11 | Foundations and Frontiers of Modern Chemistry: A Molecular and Global Perspective James G. Anderson and Gregory C. Tucci The Physical Sciences hold the key to solving unprecedented problems at the intersection of science, technology, and an array of rapidly emerging global scale challenges. The course emphasizes a molecular scale understanding of energy and entropy; free energy in equilibria, acid/base reactivity, and electrochemistry; molecular bonding and kinetics; catalysis in organic and inorganic systems; the union of quantum mechanics, nanostructures, and photovoltaics; and the analysis of nuclear energy. Case studies are used both to develop quantitative reasoning and to directly link these principles to global strategies. |